Are you finding all the mutations in your genomic sequence data? Cytognomix® Inc., a genomics company, has released this web service to help researchers quickly examine millions of DNA variants simultaneously. This world-class software currently interprets mutations that affect transcription, mRNA splicing and protein coding, and stores the results in a database that can be compared to other sources of genome variation. MutationForecaster® brings together a suite of tools that we've created in a single easy to navigate interface. Our products can find and validate mutations that others cannot.

Shannon human splicing and transcription pipelines

Genome-scale mutation analysis to predict variants affecting gene expression (mRNA splicing and transcription). Built in filtering tools aid you in determining a short list of variants most suitable for further examination in the laboratory.

View details » View publications »

Automated splice site and exon definition analyses (ASSEDA)

Examine the consequences of a single variant on mRNA splicing in detail. Potential isoform structures are displayed along with their predicted relative abundance.

View details » View publication »


Compare genome-scale splicing variants with RNA-Seq data. Reads produced by splicing mutations are compared in disease and control samples to compute p-values.

View details » View publication »

Variant effect predictor (VEP)

Predict the effect of your variants on genes and protein sequence. SIFT and PolyPhen scores are also generated.

View details »

Cytognomix user variation database (CUVD)

Store your variants generated by any of our web tools at the click of a button. Variants can be directly related to public data in HGNC, NCBI, EBI, ClinVar, as well as locus specific LOVDs. External databases can be searched with batches of variants.

View details »


A cytogenomics visual analytics decision support tool to find medical literature that relates genes to phenotypes. Used to filter disease relevant mutations from other MutationForecaster tools.

View details » View publication »

MutationForecaster is used for biomedical research. This software should not be relied upon for clinical diagnosis, prognosis, or therapy. It has not been approved by any regulatory agencies for this purpose.
MutationForecaster uses patented and patent pending technologies. See for details.